Biography

Prof. Dr. SONG Yuanjian serves as the Head of the Jiangsu Engineering and Research Center for Precision Diagnosis and Treatment of Polygenic Disorders (Xuzhou Medical University). Focusing on ischemic stroke, diabetic encephalopathy, depression, etc., he comprehensively uses biomedical big data, behavior, morphology, molecular biology, structural biology, and other technologies to study the molecular mechanisms of diseases, screen markers, and drug targets, develop diagnostic reagents and research and develop drugs at multiple levels, including group, individual, cellular, molecular and atomic. For model mice, he has developed behavioral testing devices and translated them. He has presided over 4 projects of the National Natural Science Foundation of China, 1 key research and development project in Jiangsu Province, 5 other provincial and departmental projects, 1 lateral project, and 2 university-level projects. He has published more than 30 SCI-recorded papers in international academic journals, including Aging Cell, CNS Neurosci Ther, and Mol Neurobiol, either as the corresponding author or the first author. He is the chief reviewer of one textbook and the associate editor of two textbooks. He has supervised two undergraduates who have been approved for the Innovation Training Programme of Jiangsu University Students.
https://orcid.org/0000-0002-1845-3732

Academic Awards

Prof. Dr. SONG Yuanjian received many prestigious academic awards in the field of Pathological Mechanisms of Ischemic Stroke. For instance,

Young and middle-aged academic leader of Jiangsu Province's ‘Blue and Blue Project’

Jiangsu Province ‘six peaks of talent’ high-level talent training object

Jiangsu Province ‘333 Project’ training object 

Jiangsu Province ‘333 Project’ training object

Standing member of the Cerebrovascular Disease Prevention and Control Committee of Jiangsu Preventive Medical Association

Publications

Representative publications: 

1. Ma XY, Qi CY, Xu XY, Li H, Liu CD, Wen XR, Fu YY, Liu Y, Liang J, Huang CY, Li DD, Li Y, Shen QC, Qi QZ, Zhu G, Wang N, Zhou XY, Song YJ*. PRDX1 Interfering Peptide Disrupts Amino Acids 70-90 of PRDX1 to Inhibit the TLR4/NF-κB Signaling Pathway and Attenuate Neuroinflammation and Ischemic Brain Injury. Mol Neurobiol. 2024, 61(12):10705-10721.

2. Zhou XY, Zhu YD, Gao L, Li Y, Li H, Huang CY, Liu Y, Hu AK, Ying CJ, Song YJ*. Binding of RAGE and RIPK1 induces cognitive deficits in chronic hyperglycemia-derived neuroinflammation, CNS Neurosci Ther. 2024, 30(3):e14449.

3. Liang J, Li H, Liu CD, Zhou XY, Fu YY, Ma XY, Liu D, Chen YL, Feng Q, Zhang Z, Wen XR, Zhu G, Wang N, Song YJ*. TAT-W61 peptide attenuates neuronal injury through blocking the binding of S100b to the V-domain of Rage during ischemic stroke, J Mol Med (Berl).2024, 102(2):231-245.

4. Zhou XY, Ying CJ, Hu B, Zhang YS, Gan T, Zhu YD, Wang N, Li AA, Song YJ*. Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C‐terminal AAs 2‐5 to mitogen‐activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3‐MKK3‐p38 module assembly. Aging Cell. 2022, 21(2):e13543.

5. Liu TJ, Song YJ*, Hu AK*. Neuroprotective mechanisms of mangiferin in neurodegenerative diseases. Drug Dev Res. 2021;82(4):494-502.

6. Gao YT, Cui MM, Zhong SJ, Feng CY, Alexander Kenechukwu Nwobodo, Chen B, Song YJ*, Wang YL*. Dihydroartemisinin ameliorates LPS-induced neuroinflammation by inhibiting the PI3K/AKT pathway. Metab Brain Dis. 2020, 35(4):661-672.

7. Song YJ, Shi Y, Cui MM, Li M, Wen XR, Zhou XY, Lou HQ, Wang YL, Qi DS, Tang M, Zhang XB. H2S attenuates injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module. Behav Brain Res. 2020, 384:112520.

8. Song YJ, Dai CX, Li M, Cui MM, Ding X, Zhao XF, Wang CL, Li ZL, Guo MY, Fu YY, Wen XR, Qi DS, Wang YL. The potential role of HO-1 in regulating the MLK3-MKK7-JNK3 module scaffolded by JIP1 during cerebral ischemia/reperfusion in rats. Behav Brain Res, 2019, 359:528-535.

9. Song YJ, Qin L, Yang RL, Yang F, Kenechukwu NA, Zhao XF, Zhou XY, Wen XR, Li L. Inhibition of HDAC6 alleviating lipopolysaccharide-induced p38MAPK phosphorylation and neuroinflammation in mice. Pharm Biol, 2019, 57(1):263-268.

10. Song YJ, Zhang F, Ying CJ, Kumar KA, Zhou XY. Inhibition of NF-κB activity by aminoguanidine alleviates neuroinflammation induced by hyperglycemia. Metab Brain Dis, 2017, 32(5):1627-1637.

11. Zhou XY, Zhang F, Ying CJ, Chen J, Chen L, Dong J, Shi Y, Tang M, Hu XT, Pan ZH, Xu NN, Zheng KY, Tang RX, Song YJ*. Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO/sGC/cGMP/PKG signal pathway. Behav Brain Res, 2017, 322(Pt A):70-82.

12. Zhou XY, Zhang F, Hu XT, Chen J, Tang RX, Zheng KY, Song YJ*. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice. Brain Res, 2017 Feb 15;1657:262-268.

13. Wen XR, Fu YY, Liu HZ, Wu J, Shao XP, Zhang XB, Ma K, Zhang F, Wang YW, Tang H, Han D, Zhang P, Wang SL, Xu Z, Song YJ*. Neuroprotection of sevoflurane against ischemia/reperfusion-induced brain injury through inhibiting JNK3/Caspase-3 by enhancing Akt signaling pathway. Mol Neurobiol, 2016, 53(3):1661-1671.

14. Zhang F, Fu YY, Zhou XY, Pan W, Shi Y, Wang M, Zhang XB, Qi DS,Li L,Ma K, Tang RX, Zheng KY, Song YJ*. Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation. J Neuroimmunol, 2016, 298, 1-8.

15. Wen XR, Tang M, Qi DS, Huang XJ, Liu HZ, Zhang F, Wu J, Wang YW,  Zhang XB, Guo JQ, Wang SL, Liu Y, Wang YL, Song YJ*. Butylphthalide suppresses neuronal cells apoptosis through inhibiting JNK-Caspase3 signaling pathway after brain ischemia/reperfusion in rats. Cell Mol Neurobiol, 2016, 36(7)1087-1095.

16. Wang M, Qi DS, Zhou C, Han D, Li PP, Zhang F, Zhou XY, Han M, Di JH, Ye JS, Yu HM, Song YJ*, Zhang GY. Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway. Brain Res, 2016, 1634:140-149.

17. Zhou XY, Zhang F, Hu X, Chen J, Wen XR, Sun Y, Liu Y, Tang RX, Zheng KY, Song YJ*. Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice. Physiol Behav, 2015, 151, 412-420.

18. Fu YY, Liu HZ, Song CJ, Zhang F, Liu Y, Wu J, Wen XR, Liang C, Ma K, Li L, Zhang XB, Shao XP, Sun Y, Du Y, Song YJ*. Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice. Int Immunopharmacol, 2015, 29(2), 950-956.

19. Ying CJ, Zhang F, Zhou XY, Hu XT, Chen J, Wen XR, Sun Y, Zheng KY, Tang RX, Song YJ*. Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus. Cell Mol Neurobiol, 2015, 35(7), 1027-1037.