Biography

2016--present:

Xuzhou Medical University, School of Basic Medicine, Professor in Immunology

Education

1998.06 Peking University, Immunology, Ph.D.

Publications

Representative publications: 

1.Kou Y, Zhang S, Chen J, Shen Y, Zhang Z, Huang H, Ma Y, Xiang Y, Liao L, Zhou J, Cheng W, Zhou Y, Yang H, Liu Z, Wei Y, Wang H, Wang Y. A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner. Nat Commun, 2024 Sep 10; 15(1):7914, PMID: 39256385.

2.Zhou J, Han J, Wei Y, Wang Y. Desaminotyrosine is a redox-active microbial metabolite that bolsters macrophage antimicrobial functions while attenuating IL-6 production. FASEB J, 2024 Jul 01; 38(14):e23844. PMID: 39046365.

3.Liu Z, Wang H, Zhang Z, Ma Y, Jing Q, Zhang S, Han J, Chen J, Xiang Y, Kou Y, Wei Y, Wang L, Wang Y. Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism. PLoS Negl Trop Dis. 2024 May 7;18(5):e0012163. doi: 10.1371/journal.pntd.0012163. PMID: 38713713; PMCID: PMC11101080.

4.Yang H, Wu X, Li X, Zang W, Zhou Z, Zhou Y, Cui W, Kou Y, Wang L, Hu A, Wu L, Yin Z, Chen Q, Chen Y, Huang Z, Wang Y* (*co-senior author), Gu B. A commensal protozoan attenuates Clostridioides difficile pathogenesis in mice via arginine-ornithine metabolism and host intestinal immune response. Nat Commun. 2024 Apr 2;15(1):2842. doi: 10.1038/s41467-024-47075-0. PMID: 38565558; PMCID: PMC10987486.

5.Liu Z, Sun H, Xu S, Wang H, Zhang Z, Wei Y, Kou Y, Wang Y. Dietary ingredient change induces a transient MyD88-dependent mucosal enteric glial cell response and promotes obesity. Nutr Neurosci. 2023 Dec;26(12):1183-1193. doi:10.1080/1028415X.2022.2142129. Epub 2022 Nov 7. PMID: 36342063.

6.Liu Z, Xu S, Zhang Z, Wang H, Jing Q, Zhang S, Liu M, Han J, Kou Y, Wei Y, Wang L, Wang Y. FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice. Free Radic Biol Med. 2022 Nov 1;192:115-129. doi: 10.1016/j.freeradbiomed.2022.09.011. Epub 2022 Sep 20. PMID: 36150559.

7.Wei Y, Liu M, Han J, Huang H, Xu S, Zhang S, Jing Q, Wang H, Bu H, Kou Y, Liu Z, Zheng K, Wang Y. A tyrosine catabolic intermediate 4-hydroxyphenylpyruate attenuates murine endotoxic shock by blocking NLRP3 inflammasome activation. Int Immunopharmacol. 2022 Oct;111:109098. doi: 10.1016/j.intimp.2022.109098. Epub 2022 Aug 6. PMID: 35944460.

8.Kou Y, Zheng X, Meng L, Liu M, Xu S, Jing Q, Zhang S, Wang H, Han J, Liu Z, Wei Y, Wang Y. The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota. Front Immunol. 2022 Feb 4;13:773341. doi: 10.3389/fimmu.2022.773341. PMID: 35185877; PMCID: PMC8854854.

9.Kou Y, Meng L, Zhang S, Zheng X, Liu M, Xu S, Jing Q, Wang H, Han J, Liu Z, Wei Y, Wang Y. A Murine Commensal Protozoan Influences Host Glucose Homeostasis by Facilitating Free Choline Generation. Appl Environ Microbiol. 2022 Mar 22;88(6):e0241321. doi: 10.1128/aem.02413-21. Epub 2022 Jan 26. PMID: 35080909;  PMCID: PMC8939315.

10.Kou YB, Yan XQ, Jing QY, Zhang SH, Liu ZZ, Wei YX, Wang YG. LIGHT (TNFSF14) inhibits glucose uptake of adipocytes by downregulating GLUT4 expression via AKT signaling pathway. Biochem Biophys Res Commun. 2021 Oct 28;583:106-113. doi:10.1016/j.bbrc.2021.10.061. Epub ahead of print. PMID: 34735871.