Biography

Prof  YAN Chao, an associate professor at the Department of Pathogenic Biology and Immunology, School of Basic Medicine, Xuzhou Medical University, and a visiting scholar at the University of California, San Diego, USA. He has been selected for talent programs such as the "333 High-level Talent Training Project" (the third level) in Jiangsu Province and the "Qinglan Project" in Jiangsu Province. He has won honors and awards including the First Prize in the Natural Science Award of Colleges and Universities in Jiangsu Province (2nd among 5, 2018), the First Prize in the 6th Huaihai Science and Technology Innovation Award (3rd among 10, 2018), and the Jiangsu Provincial Government Scholarship for Studying Abroad (2016). He serves as a young editorial board member of Decoding Infection and Transmission, Chinese Journal of Parasitology and Parasitic Diseases, and Chinese Journal of Schistosomiasis Control, and is an academic editorial board member of PLoS Negl Trop Dis. He has successively presided over nearly 10 projects, including the National Natural Science Foundation, the Natural Science Foundation of Jiangsu Province, and major natural science research projects of colleges and universities in Jiangsu Province. He is mainly engaged in research on the pathogenesis of parasitic infections. As the first author or corresponding author, he has published more than 20 SCI papers in international mainstream journals such as Proc Natl Acad Sci U S A and Hepatology and has obtained 3 national invention patents.

Education

2014--2017, Ph.D in the major of Microbiology, Department of Pathogenic Biology and Immunology, Laboratory of Infection and Immunity, Xuzhou Medical University, under the supervision of Professor Kui-Yang Zheng

2007--2010, Master in the major of Preventive Veterinary, South China Agricultural University, under the supervision of Professor Xing-Quan Zhu

2003--2007, Bachelor in Qingdao Agricultural University, Veterinary Science

Publications

Representative publications: 

1.Yan C#,*, Zhou QY#, Wu J#, Xu N, Du Y, Li J, Liu JX, Koda S, Zhang BB, Yu Q, Yang HM, Li XY, Zhang B, Xu YH, Chen JX, Wu Z, Zhu XQ, Tang RX*, Zheng KY*. Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries. Proc Natl Acad Sci U S A. 2021;118(46): e2102206118. 

2.Yan C#, Koda S#, Wu J, Zhang BB, Yu Q, Netea MG, Tang RX*, Zheng KY*. Roles of trained immunity in the pathogenesis of cholangiopathies: a therapeutic target. Hepatology. 2020; 72(5):1838-1850. 

3.Zhang B, Li J, Zong X, Wang J, Xin L, Song H, Zhang W, Koda S, Hua H, Zhang B, Yu Q, Zheng KY*, Yan C*. FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum infected mice. PLoS Negl Trop Dis. 2022;16(8):e0010651.  

4.Koda S#, Zhang B#, Zhou QY, Xu N, Li J, Liu JX, Liu M, Lv ZY, Wang JL, Shi Y, Gao S, Yu Q, Li XY, Xu YH, Chen JX, Tekengne BOT, Adzika GK, Tang RX, Sun H, Zheng KY*, Yan C*. β2-Adrenergic receptor enhances the alternatively activated macrophages and promotes biliary injuries caused by helminth infection. Front Immunol. 2021;12:754208.

5.Yan C#, Fang F#, Zhang YZ, Dong X, Wu J, Liu HL, Fan CY, Koda S, Zhang BB, Yu Q, Wang L, Wang YG, Chen JX, Zheng KY*. Recombinant CsHscB of carcinogenic liver fluke Clonorchis sinensis induces IL-10 production by binding with TLR2. PLoS Negl Trop Dis. 2020;14(10):e0008643.

6.Yan C#, Xu N#, Liu M, Jiang Z, Wu J, Koda S, Chen Y, Zhang B, Yu Q, Xu YH, Wu JL, Zheng KY. Interleukin-33 deficiency prevents biliary injuries and repairments caused by Clonorchis sinensis via restraining type 2 cytokines. Parasit Vectors. 2022;15(1):386.

7.Yan C#,*, Wu J#, Xu N, Li J, Zhou QY, Yang HM, Cheng XD, Liu JX, Dong X, Koda S, Zhang BB, Yu Q, Chen JX, Tang RX, Zheng KY*. TLR4 deficiency exacerbates biliary injuries and peribiliary fibrosis caused by Clonorchis sinensis in a resistant mouse strain. Front Cell Infect Microbiol. 2021;10:526997.

8.Zhou QY, Yang HM, Liu JX, Xu N, Li J, Shen LP, Zhang YZ, Koda S, Zhang BB, Yu Q, Chen JX, Zheng KY*, Yan C*. MicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7. Parasit Vectors. 2021;14(1):472.

9.Hua H*, Zhao QQ*, Kalagbor MN, Yu GZ, Liu M, Bian ZR, Zhang BB, Yu Q, Xu YH, Tang RX, Zheng KY#, Yan C#. Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model. World J Gastroenterol. 2024;30(5):471-484.

10.Yu Q, Koda S, Xu N, Li J, Wang JL, Liu M, Liu JX, Zhang Y, Yang HM, Zhang BB, Li XY, Li XC, Tang RX, Zheng KY, Yan C#. CsHscB derived from a liver fluke Clonorchis Sinensis ameliorates cholestatic hepatic fibrosis in a mouse model of sclerosing cholangitis. Curr Mol Med. 2024;24:505-515.