Biography
Prof. Dr. YANG Jing is the Principal Investigator of the tumor immunology research group. She graduated from Kochi University, Japan, and successively carried out post-doc training in the Medical School of Kochi University and UNC, respectively. She has published more than 50 SCI papers, with 20 first or corresponding authorship papers in top academic journals such as Blood, Cancer Research and Leukemia. More information about Prof. Dr. Yang’s publication record can be accessed via the link below:
https://orcid.org/0000-0002-2624-5028
Academic Awards
Prof. Dr. YANG Jing received many prestigious academic awards. For instance,
JSPS Postdoctoral Fellow for Overseas Researchers
Jiangsu Shuangchuang program
Jiangsu Distinguished professor
Publications
Representative publications:
1. Zhao J, Yao C, Qin Y, Zhu H, Guo H, Ji B, Li X, Sun N, Li R, Wu Y, Zheng K*, Pan Y*, Zhao T*, Yang J*. Blockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner. Cell Death Dis. 2024 Feb 8;15(2):120.
2. Li X, Chen X, Gong S, Zhao J, Yao C, Zhu H, Xiao R, Qin Y, Li R, Sun N, Li X, Dong F, Zhao T, Pan Y*, Yang J*. Platelets promote CRC by activating the C5a/C5aR1 axis via PSGL-1/JNK/STAT1 signaling in tumor-associated macrophages. Theranostics. 2023 Mar 27;13(6):2040-2056.
3. Li R, Li X, Zhao J, Meng F, Yao C, Bao E, Sun N, Chen X, Cheng W, Hua H, Li X, Wang B, Wang H, Pan X*, You H*, Yang J*, Ikezoe T. Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation. Theranostics. 2022 Jan 1;12(2):976-998.
4. Chen X, Wang C, Sun N, Pan S, Li R, Li X, Zhao J, Tong H, Tang Y, Han J, Qiao J, Qiu H, Wang H*, Yang J*, Ikezoe T. Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production. Theranostics. 2021 Mar 4;11(10):4655-4671.
5. Yang J*, Jin A, Han J, Chen X, Zheng J*, Zhang Y*. MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo. Cancer Res. 2021 Feb 15;81(4):898-909.
6. Li R, Sun N, Chen X, Li X, Zhao J, Cheng W, Hua H, Fukatsu M, Mori H, Takahashi H, Ohkawara H, Fukami M, Okamoto M, Hamazaki Y, Zheng K, Yang J*, Ikezoe T*. JAK2V617F Mutation Promoted IL-6 Production and Glycolysis via Mediating PKM1 Stabilization in Macrophages. Front Immunol. 2021 Feb 8;11:589048.
7. Sun N, Meng F, Zhao J, Li X, Li R, Han J, Chen X, Cheng W, Yang X, Kou Y, Zheng K*, Yang J*, Ikezoe T. Aurka deficiency in the intestinal epithelium promotes age-induced obesity via propionate-mediated AKT activation. Int J Biol Sci. 2021 Mar 25;17(5):1302-1314.
8. Chen X, Sun N, Li R, Sang X, Li X, Zhao J, Han J, Yang J*, Ikezoe T. Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis. Int J Biol Sci. 2021 Mar 25;17(5):1263-1276.
9. Han J, Jiang Z, Wang C, Chen X, Li R, Sun N, Liu X, Wang H, Hong L, Zheng K*, Yang J*, Ikezoe T. Inhibition of Aurora-A Promotes CD8+ T-Cell Infiltration by Mediating IL10 Production in Cancer Cells. Mol Cancer Res. 2020 Oct;18(10):1589-1602.
10. Yang J, Ikezoe T, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y, Komatsu N, Bandobashi K, Togitani K, Koeffler HP, Taguchi H, Yokoyama A. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood. 2007;110(6):2034-40.
