Biography
Prof. Dr. LI HuiJuan is working for the Research Center for Biochemistry and Molecular Biology (Xuzhou Medical University). She is the Principal Investigator of the psychiatric genetics and brain development research group. She received her Ph.D. diploma in genetics from the Kunming Institute of Zoology of the Chinese Academy of Sciences and carried out post-doc research work at Fudan University in the field of stem cell and brain organoids. She has studied the pathogenesis of psychiatric disorders from the perspectives of genetics and human brain development. She has published more than 15 SCI papers, with 4 first or corresponding authorship papers in top academic journals such as JAMA Psychiatry, Schizophrenia Bulletin, Neuropsychopharmacology, Translational Psychiatry.
Publications
Representative publications:
1. Li HJ#, Yu X#, Xu J#, Chen J, Cheng T, Chung S*, Shu Y*, Shao Z*. Calneuron 1 reveals the pivotal roles in schizophrenia via perturbing human forebrain development and causing hallucination-like behavior in mice. bioRxiv, 2024.2004.2016.589839 (2024).
2. Li HJ#, Zhang C#, Hui L#, Zhou DS, Li Y, Zhang CY, Wang C, Wang L, Li W, Yang Y, Qu N, Tang J, He Y, Zhou J, Yang Z, Li X, Cai J, Yang L, Chen J, Fan W, Tang W, Tang W, Jia QF, Liu W, Zhuo C, Song X, Liu F, Bai Y, Zhong BL, Zhang SF, Chen J, Xia B, Lv L, Liu Z, Hu S, Li XY, Liu JW, Cai X, Yao YG, Zhang Y, Yan H, Chang S, Zhao JP, Yue WH, Luo XJ, Chen X, Xiao X, Fang Y*, Li M*; Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals. JAMA Psychiatry. 2021 Mar 1;78(3):320-330.
3. Li HJ, Zhang C, Cai X, Wang L, Luo F, Ma Y, Li M*, Xiao X*. Genome-wide Association Study of Creativity Reveals Genetic Overlap With Psychiatric Disorders, Risk Tolerance, and Risky Behaviors. Schizophrenia Bulletin, 2020 Sep 21;46(5):1317-1326.
4. Li HJ#, Qu N#, Hui L#, Cai X, Zhang CY, Zhong BL, Zhang SF, Chen J, Xia B, Wang L, Jia QF, Li W, Chang H, Xiao X*, Li M*, Li Y*. Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data. Translational Psychiatry. 2020 Mar 17;10(1):98.
5. Li HJ#, Chang H#, Song X#, Liu W, Li L, Wang L, Yang Y, Zhang L, Li W, Zhang Y, Zhou DS, Li X, Zhang C, Fang Y, Sun Y, Dai JP, Luo XJ, Yao YG, Xiao X*, Lv L*, Li M*. Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder. Neuropsychopharmacology. 2019 Aug;44(9):1552-1561.
6. Li HJ#, Zhou DS#, Chang H#, Wang L, Liu W, Dai SX, Zhang C, Cai J, Liu W, Li X, Fan W, Tang W, Tang W, Liu F, He Y, Bai Y, Hu Z, Xiao X, Gao L*, Li M*. Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder. Journal of Psychiatric Research. 2019 Aug:115:165-175.
7. Wang JY#, Li XY#, Li HJ#, Liu JW, Yao YG, Li M, Xiao X*, Luo XJ*. Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene. Schizophrenia Bulletin. 2021 Aug 21;47(5):1364-1374.
8. Chang H#, Cai X#, Li HJ#, Liu WP, Zhao LJ, Zhang CY, Wang JY, Liu JW, Ma XL, Wang L, Yao YG, Luo XJ, Li M*, Xiao X*. Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus. Biological Psychiatry, 2021 Feb 1;89(3):246-255.
9. Xu J#, Fang S#, Deng S, Li HJ, Lin X, Huang Y, Chung S, Shu Y, Shao Z. Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nature Biomedical Engineering. 2023 Mar;7(3):253-269.
10. Xu J#, Kong Y#, Wang N, Li HJ, Li Y, Liu Z, Yang Y, Yu X, Liu H, Ding J, Wang Y*, Zhao R*, Shao Z*. Personalized Human Astrocyte-Derived Region-Specific Forebrain Organoids Recapitulate Endogenous Pathological Features of Focal Cortical Dysplasia. Advanced science. 2024 Dec 31:e2409774.
