Biography
Dr. DUAN Xinpeng is a professor and master’s supervisor at the Department of Physiology at Xuzhou Medical University. His primary research interests focus on renal ion channels and their roles in blood pressure regulation and potassium balance homeostasis. Using a variety of gene knockout mouse models, Dr. Duan explores the interactions between renal ion channels, such as Kir4.1, Kir5.1, ROMK, and related transporters, employing electrophysiology, renal clearance techniques, and molecular biology methods. Dr. Duan has published over 20 academic papers in prestigious journals such as J Am Soc Nephrol, Hypertension, JCI Insight, Acta Physiol, and AJP-Renal Physiology. He is the principal investigator of a National Natural Science Foundation of China project and a Jiangsu Provincial University General Fund project. In 2024, he was selected for the Jiangsu Association for Science and Technology’s Young Science and Technology Talent Support Program.
Education
Ph.D. in Physiology, Harbin Medical University (2013-2018)
Postdoctoral Fellow in Pharmacology, New York Medical College (2019-2023)
Publications
Representative publications:
1.Duan XP, Zheng JY, Xiao Y, Zhang CB, Lin DH, Wang WH. Angiotensin II-Type-1a Receptor and Renal K + Wasting during Overnight Low-Na + Intake. J Am Soc Nephrol. 2024 Nov 1;35(11):1478-1492.
2.Duan XP, Zhang CB, Wang WH, Lin DH. Role of calcineurin in regulating renal potassium excretion: Mechanisms of calcineurin inhibitor-induced hyperkalemia. Acta Physiol (Oxf). 2024 Aug;240(8):e14189.
3.Duan XP, Zheng JY, Jiang SP, Wang MX, Zhang C, Chowdhury T, Wang WH, Lin DH. mTORc2 in Distal Convoluted Tubule and Renal K + Excretion during High Dietary K+ Intake. J Am Soc Nephrol. 2024 May 24;35(9):1149–63.
4.Duan XP, Xiao Y, Su XT, Zheng JY, Gurley S, Emathinger J, Yang CL, McCormick J, Ellison DH, Lin DH, Wang WH. Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na+ Channel (ENaC). Hypertension. 2024 Jan;81(1):126-137.
5.Zhang DD, Duan XP, Mutig K, Rausch F, Xiao Y, Zheng JY, Lin DH, Wang WH. Calcineurin inhibitors stimulate Kir4.1/Kir5.1 of the distal convoluted tubule to increase NaCl cotransporter. JCI Insight. 2023 Apr 10;8(7):e165987.
6.Duan XP, Wu P, Zhang DD, Gao ZX, Xiao Y, Ray EC, Wang WH, Lin DH. Deletion ofKir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl- cotransporter. Am J Physiol Renal Physiol. 2021 Jun 1;320(6):F1045-F1058.
7.Zhang DD, Duan XP, Xiao Y, Wu P, Gao ZX, Wang WH, Lin DH. Deletion of renal Nedd4-2 abolishes the effect of high sodium intake (HS) on Kir4.1, ENaC, and NCC and causes hypokalemia during high HS. Am J Physiol Renal Physiol. 2021 May 1;320(5):F883-F896.
8.Duan XP, Gu L, Xiao Y, Gao ZX, Wu P, Zhang YH, Meng XX, Wang JL, Zhang DD, Lin DH, Wang WH, Gu R. Norepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule. Hypertension. 2019 Jan;73(1):112-1.
