Biography
2018.01--Currently, Department of Physiology, Xuzhou Medical University, Lecturer
2015.09--2017.12, Department of Physiology, Xuzhou Medical University, Teaching assistant
2018.11--2019.10, Imperial College London, Visiting scholar.
Education
2018.09--2022.06, Xuzhou Medical University, Physiology, PhD. supervisor: Hong Sun
2012.09--2015.06, Xuzhou Medical University, Physiology, Master, supervisor: Hong Sun
2007.09--2012.06, Xuzhou Medical College, Clinical Medicine, MD.
Publications
Representative publications:
1. Zhou Y, Yin Z, Cui J, Wang C, Fu T, Adu-Amankwaah J, Fu L, Zhou X. 16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-Adrenergic receptor. Mol Cell Endocrinol. 2024 Jun 1;587:112200.
2. Sang, L., Fu, L., Gao, L., Adu-Amankwaah, J., Gong, Z., Li, T., Ma, Z., Wang, Z., Xu, J., & Sun, H. (2024). GPER-1 Rapid Regulation Influences p-Akt Expression to Resist Stress-Induced Injuries in a Sex-Specific Manner. Physiological research, 73(5), 831–839.
3. Fu L, Adu-Amankwaah J, Sang L, Tang Z, Gong Z, Zhang X, Li T, Sun H. Gender differences in GRK2 in cardiovascular diseases and its interactions with estrogen. Am J Physiol Cell Physiol. 2023 Feb 1;324(2):C505-C516.
4.Fu L, Zhang H, Machuki JO, Zhang T, Han L, Sang L, Wu L, Zhao Z, Turley MJ, Hu X, Hou H, Li D, Harding SE, Sun H. Reply to: Estrogens for protection from an index and recurrent episodes of takotsubo syndrome? J Endocrinol. 2021 Aug 12;250(3):L3. doi: 10.1530/JOE-21-0227. PMID: 34382942.
5.Fu L, Zhang H, Ong'achwa Machuki J, Zhang T, Han L, Sang L, Wu L, Zhao Z,
James Turley M, Hu X, Hou H, Li D, E Harding S, Sun H. GPER mediates estrogen
cardioprotection against epinephrine-induced stress. J Endocrinol. 2021 May 20;249(3):209-222. doi: 10.1530/JOE-20-0451. PMID: 33847279.
6.Fu L, Liu Y, Wang J, Sun Y, Zhang L, Wu T, Li Y, Wang B, Huang S, Bu H, Sun H. Cardioprotection by Low-dose of Estrogen and Testosterone at the Physiological Ratio on Ovariectomized Rats During Ischemia/Reperfusion Injury. J Cardiovasc Pharmacol. 2017 Aug;70(2):87-93.
7.Bao L, Lu F, Chen H, Min Q, Chen X, Song Y, Zhao B, Bu H, Sun H. High concentration of epigallocatechin-3-gallate increased the incidences of arrhythmia and diastolic dysfunction via β2-adrenoceptor. J Food Sci. 2015 Mar;80 (3):T659-63. doi: 10.1111/1750-3841.12803. Epub 2015 Feb 10. PMID:25676191.
8.Hou H, Zhao Z, Machuki JO, Zhang L, Zhang Y, Fu L, Wu J, Liu Y, Harding SE, Sun H. Estrogen deficiency compromised the β<sub>2</sub>AR-Gs/Gi coupling: implications for arrhythmia and cardiac injury. Pflugers Arch. 2018 Mar;470(3):559-570.
9. Machuki JO, Zhang HY, Geng J, Fu L, Adzika GK, Wu L, Shang W, Wu J, Kexue L,Zhao Z, Sun H. Estrogen regulation of cardiac cAMP-L-type Ca<sup>2+</sup> channel pathway modulates sex differences in basal contraction and responses to β<sub>2</sub>AR-mediated stress in left ventricular apical myocytes. Cell Commun Signal. 2019 Apr 15;17(1):34. doi: 10.1186/s12964-019-0346-2.
10. Jiao L, Machuki JO, Wu Q, Shi M, Fu L, Adekunle AO, Tao X, Xu C, Hu X, Yin Z,Sun H. Estrogen and calcium handling proteins: new discoveries and mechanisms in cardiovascular diseases. Am J Physiol Heart Circ Physiol. 2020 Apr1;318(4):H820-H829. doi: 10.1152/ajpheart.00734.2019. Epub 2020 Feb 21.
11. Couch LS, Fiedler J, Chick G, Clayton R, Dries E, Wienecke LM, Fu L, Fourre
J, Pandey P, Derda AA, Wang BX, Jabbour R, Shanmuganathan M, Wright P, Lyon AR, Terracciano CM, Thum T, Harding SE. Circulating microRNAs predispose to
takotsubo syndrome following high-dose adrenaline exposure. Cardiovasc Res. 2022 Jun 22;118(7):1758-1770. doi: 10.1093/cvr/cvab210. PMID: 34155498; PMCID: PMC9214785.
