Biography

2019.12--2020.12  Visiting scholar in Internal Medicine

                 Division of Cardiovascular Medicine

                 Dept. of Internal Medicine

                 University of Iowa Carver College of Medicine, USA

2024.07--Present  Associate professor in Physiology

                 Dept. of Physiology, Xuzhou Medical university, China

2015.08--2024.06  Lecturer in Physiology

                 Dept. of Physiology, Xuzhou Medical university, China

2013.07--2015.06   Lecturer in Preventive Medicine

                 Dept. of Preventive Medicine, Yangtze University, China

Education

2008.09—2013.06  Ph.D. in Pathology and Pathophysiology

Dept. of Pathophysiology, Tongji Medical College of Huazhong University of Science and Technology, China

Thesis: GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension.

Mentors: Qinghua Hu

2003.09—2008.07  M.D. in Preventive Medicine

Dept. of Preventive Medicine, Tongji Medical College of Huazhong University of Science and Technology, China

Publications

Representative publications: 

1.Tan R, Li J, Liu F, Liao P, Ruiz M, Dupuis J, Zhu L, Hu Q. Phenylalanine induces pulmonary hypertension through calcium-sensing receptor activation. Am J Phisiol LCMP. 2020 Dec 1;319(6):L1010-L1020.

2.Tan R, Li J, Peng X, Zhu L, Cai L, Wang T, Su Y, Irani K, Hu Q. GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension. Cardiovasc Res. 2013 Oct 1;100(1):19-27.

3.Tan R, You Q, Cui J, Wang M, Song N, An K, Lin L, Adu-Amankwaah J, Yuan J, Sun H. Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38. Phytomedicine. 2023 Jan;109:154590.

4.Tan R, You Q, Yu D, Xiao C, Adu-Amankwaah J, Cui J, Zhang T. Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertension. Front Cardiovasc Med. 2022 Nov 30;9:945854.

5.Tan R, Li C, Xu C, Wu Q, Gao L, Shi Y, Cui J. Targeting JP2: A New Treatment for Pulmonary Hypertension. Oxid Med Cell Longev. 2021 Aug 6;2021:2003446.

6.Su Y, Tan R, Sun M, Yuan L, Ruiz M, Dupuis J, Hu Q, Zhu L. MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke-Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFκB (Nuclear Factor κB)-CaSR (Calcium-Sensing Receptor) Cascade. Hypertension. 2022 Dec;79(12):2721-2732.

7.Zhang M, Liu Q, Meng H, Duan H, Liu X, Wu J, Gao F, Wang S, Tan R, Yuan J. Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther. 2024 Jan 8;9(1):12.

8.You Q, Song H, Zhu Z, Wang J, Wang R, Du M, Fu Y, Yuan J, Tan R. Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes. Cell Mol Biol Lett. 2024 Dec 18;29(1):155.

9.Wang H, Yu W, Wang Y, Wu R, Dai Y, Deng Y, Wang S, Yuan J, Tan R. p53 contributes to cardiovascular diseases via mitochondria dysfunction: A new paradigm. Free Radic Biol Med. 2023 Sep 29;208:846-858.

10.Adu-Amankwaah J, Bushi A, Tan R, Adekunle AO, Adzika GK, Ndzie Noah ML, Nadeem I, Adzraku SY, Koda S, Mprah R, Cui J, Li K, Wowui PI, Sun H. Estradiol mitigates stress-induced cardiac injury and inflammation by downregulating ADAM17 via the GPER-1/PI3K signaling pathway. Cell Mol Life Sci. 2023 Aug 12;80(9):246.

11.Wang S, Wu J, Li X, Tan R, Chen L, Yang L, Dai F, Ma L, Xu L, Wang Z, Zhao G, Ge J, Zou Y. CXCR6 Mediates Pressure Overload-Induced Aortic Stiffness by Increasing Macrophage Recruitment and Reducing Exosome-miRNA29b. J Cardiovasc Transl Res. 2023 Apr;16(2):271-286.

12.Mo Y, Adu-Amankwaah J, Qin W, Gao T, Hou X, Fan M, Liao X, Jia L, Zhao J, Yuan J, Tan R. Unlocking the Prognostic Potential of Long Non-Coding RNAs: A Machine Learning Approach for Precise Cancer Patient Prognosis. Annals of Medicine. 2023;55(2):2279748.

13.Wang X, Yu Q, Liao X, Fan M, Liu X, Liu Q, Wang M, Wu X, Huang C, Tan R, and Yuan J. Mitochondria dysfuction in arrhythmia and myocardial hypertrophy. Reviews in cardiovascular medicine. 2023, 24(12):364.

14.Wang H, Lin Y, Zhang R, Chen Y, Ji W, Li S, Wang L, Tan R, Yuan J. Programmed Exercise Attenuates Familial Hypertrophic Cardiomyopathy in Transgenic E22K Mice via Inhibition of PKC-α/NFAT Pathway. Front Cardiovasc Med. 2022 Feb 21;9:808163.

15.Zhang H, Fang H, Liu D, Zhang Y, Adu-Amankwaah J, Yuan J, Tan R, Zhu J. Applications and challenges of rhodopsin-based optogenetics in biomedicine. Front Neurosci. 2022 Sep 23;16:966772.

16.Wu Z, Tan R, Zhu L, Yao P, Hu Q. Protein S-Palmitoylation and Lung Diseases. Adv Exp Med Biol. 2021;1304:165-186.

17.Shi Y, Adu-Amankwaah J, Zhao Q, Li X, Yu Q, Bushi A, Yuan J, Tan R. Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms. Heliyon. 2024 Mar 1;10(5):e27207.

18.Song H, Adu-Amankwaah J, Zhao Q, Yang D, Liu K, Bushi A, Zhao J, Yuan J, Tan R. Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). Int J Oncol. 2024 Jun;64(6):61. doi: 10.3892/ijo.2024.5649. Epub 2024 May 2.

19.Adu-Amankwaah J, Adekunle AO, Tang Z, Bushi A, Tan R, Fu L, Gong Z, Ma Z, Mprah R, Noah MLN, Wowui PI, Ong'achwa Machuki J, Pan X, TaoLi, Sun H. Estradiol contributes to sex differences in resilience to septic-induced metabolic dysregulation and dysfunction in the heart via GPER-1-mediated PPARδ/NLRP3 signaling. Metabolism. 2024 May 16:155934.

20.Ndzie Noah ML, Mprah R, Wowui PI, Adekunle AO, Adu-Amankwaah J, Tan R, Gong Z, Li T, Fu L, Machuki JO, Zhang S, Sun H. CD73/adenosine axis exerts cardioprotection against hypobaric hypoxia-induced metabolic shift and myocarditis in a sex-dependent manner. Cell Commun Signal. 2024 Mar 7;22(1):166. doi: 10.1186/s12964-024-01535-8.

21.Meng K, Liu Q, Qin Y, Qin W, Zhu Z, Sun L, Jiang M, Adu-Amankwaah J, Gao F, Tan R, Yuan J. Mechanism of mitochondrial oxidative phosphorylation disorder in male infertility. Chin Med J (Engl). 2024 Jun 7. doi: 10.1097/CM9.0000000000003126.

22.Gao L, Li X, Tan R, Cui J, Schmull S. Human-derived decellularized extracellular matrix scaffold incorporating autologous bone marrow stem cells from patients with congenital heart disease for cardiac tissue engineering. Biomed Mater Eng. 2022;33(5):407-421. doi: 10.3233/BME-211368.

23.Wu Q, Zhang KJ, Jiang SM, Fu L, Shi Y, Tan RB, Cui J, Zhou Y. p53: A Key Protein That Regulates Pulmonary Fibrosis. Oxid Med Cell Longev. 2020 Nov 29;2020:6635794. doi: 10.1155/2020/6635794. eCollection 2020.

24.Peng X, Li J, Yu X, Tan R, Zhu L, Wang J, Wang R, Gu G, Liu Q, Ren L, Wang C, Hu Q. Therapeutic effectiveness of bone marrow-derived mesenchymal stem cell administration against acute pulmonary thromboembolism in a mouse model. Thromb Res. 2015 May;135(5):990-9.