Biography

Dr. YOU Hongjuan received her Ph.D. diploma from Soochow University, China. She has published more than 30 SCI papers, with 10 first or corresponding authorship papers in top academic journals such as mBio, British Journal of Cancer,  International journal of biological, Journal of Virology. She presided over a number of research and teaching projects, such as National Natural Science Foundation of China.

Publications

Representative publications:

1.You HJ, Zheng SS, Huang Z, Lin Y, Shen Q*, Zheng CF*.  Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling. mBio. 2019;10(3).

2.You HJ#, Lin Y#, Lin F, Yang M, Li J, Zhang R, Huang Z, Shen Q, Tang RX, Zheng CF*. β-Catenin Is Require Required for cGAS/STING Signaling Pathway but Antagonized by HSV-1 US3 Protein. Journal of virology. 2019; 94:5 e01847-19.

3.You HJ#, Yuan H#, Fu W, Su CH, Wang W, Cheng T, Zheng CF*. Herpes simplex virus type 1 abrogates the antiviral activity of Ch25h via its virion host shutoff protein. Antiviral research. 2017; 143:69-73.

4.You HJ#, Yuan DC#, Li Q, Zhang N, Kong DL, Yu T, Liu XY, Kong FY, Zheng KY, Tang RX*. Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis. International journal of biological macromolecules. 2023; 226, 996-1009.

5.You HJ#, Zhang N, Yu T, Ma LH, Li Q, Wang X, Yuan DC, Kong DL, Liu XY, Hu W, Liu D, Kong FY, Zheng KY, Tang RX. Hepatitis B virus X protein promotes MAN1B1 expression by enhancing stability of GRP78 via TRIM25 to facilitate hepatocarcinogenesis. Br J Cancer. 2023 Apr;128(6):992-1004. 

6.You HJ#, Kong FY#, Zhou K, Wei X, Hu L, Hu W, Luo W, Kou YB, Liu XY, Chen X, Zheng KY, Tang RX*. HBX protein promotes LASP-1 expression through activation of c-Jun in human hepatoma cells. J Cell Physiol. 2018; 1-13.

7.Kong FY#, Zhou K#, Zhu T#, Lian Q, Tao Y, Li N, Tu T, Bi YW, Yang X, Pan XC, Li Sh, You HJ*, Zheng KY, Tang RX*. Interleukin-34 mediated by hepatitis B virus X protein via CCAAT/enhancer-binding protein α contributes to the proliferation and migration of hepatoma cells. Cell Proliferation. 2019; 233: 7279-7291.

8.You HJ#, Ma LH, Wang X, Wang YX, Zhang HY, Bao ES, Zhong YJ, Liu XY, Kong DL, Zheng KY, Kong FY, Tang RX. Hepatitis B virus core protein stabilizes RANGAP1 to upregulate KDM2A and facilitate hepatocarcinogenesis. Cell Oncol (Dordr). 2024 Apr;47(2):639-655.

9.You HJ#, Li Q, Ma LH, Wang X, Zhang HY, Wang YX, Bao ES, Zhong YJ, Kong DL, Liu XY, Kong FY*, Zheng KY, Tang RX*. Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis. J Mol Cell Biol. 2024 Sep 30;16(4): mjae014.

10.You HJ*, Zheng C*. A Guideline Strategy for Identifying a Viral Gene/Protein Evading Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:9-18.