Biography
Prof. Zheng, MD, PhD, the former President of Xuzhou Medical University. Professor Zheng is the former director of Jiangsu Key Laboratory of Immunity and Metabolism. In recent years, using biliary tract diseases caused by Clonorchis sinensis infection as a research model, he has systematically investigated the new mechanisms of innate immunity in biliary tract injury and carcinogenesis induced by C. sinensis. Professor Zheng has published more than 50 papers in top journals including Hepatology, Microbiome, PNAS and J Clin Invest.
More information about Prof. Dr. Zheng’s publication record can be accessed via the link below: https://pubmed.ncbi.nlm.nih.gov/?term=Zheng%20Kuiyang%20and%20Xuzhou%20Medical% 20University&sort=date
Academic Awards
Prof. Dr. ZHENG Kuiyang received many prestigious academic awards and positions in the field of and Hepatology and immunology. For instance,
The vice chairman of Jiangsu Immunology Society,
The Member of the Working Committee for the Accreditation of Medical Education (WCAME) of Ministry of Education (MoE).
Honored with the Special Government Allowances Experts of the State Council
The Outstanding Mid-Aged Experts of Jiangsu Province.
Publications
Representative publications:
1. Guo H, Xu J, Situ J, Li C, Wang X, Hou Y, Yang G, Wang L, Ying D, Li Z, Wang Z, Su J, Ding Y, Zeng D, Zhang J, Ding X, Wu S, Miao W, Tang R, Lu Y, Kong H, Zhou P, Zheng Z, Zheng K*, Pan X*, Sridhar S*, Wang W*. Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans. Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2416255121
2.Pan W, Zhao J, Wu J, Xu D, Meng X, Jiang P, Shi H, Ge X, Yang X, Hu M, Zhang P, Tang R, Nagaratnam N, Zheng K*, Huang XF*, Yu Y*. Dimethyl itaconate ameliorates cognitive impairment induced by a high-fat diet via the gut-brain axis in mice. Microbiome. 2023 Feb 21;11(1):30.
3.Ge X, Zheng M, Hu M, Fang X, Geng D, Liu S, Wang L, Zhang J, Guan L, Zheng P, Xie Y, Pan W, Zhou M, Zhou L, Tang R, Zheng K*, Yu Y*, Huang XF*. Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models. J Clin Invest. 2023 Feb 15;133(4):e154612.
4.Yan C#,*, Zhou QY#, Wu J#, Xu N, Du Y, Li J, Liu JX, Koda S, Zhang BB, Yu Q, Yang HM, Li XY, Zhang B, Xu YH, Chen JX, Wu Z, Zhu XQ, Tang RX*, Zheng KY*. Csi-let-7a-5p delivered by extracellular vesicles from a liver fluke activates M1-like macrophages and exacerbates biliary injuries. Proc Natl Acad Sci U S A. 2021, 16;118(46): e2102206118.
5.Shi H, Ge X, Ma X, Zheng M, Cui X, Pan W, Zheng P, Yang X, Zhang P, Hu M, Hu T, Tang R, Zheng K, Huang XF, Yu Y. A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites. Microbiome. 2021, 9(1):223.
6.Yan C#, Koda S#, Wu J, Zhang BB, Yu Q, Netea MG, Tang RX*, Zheng KY*. Roles of Trained Immunity in the Pathogenesis of Cholangiopathies: A Therapeutic Target. Hepatology 2020, 72(5): 1838-1850.
7.Shi H, Yu Y*, Lin D, Zheng P, Zhang P, Hu M, Wang Q, Pan W, Yang X, Hu T, Li Q, Tang R, Zhou F, Zheng K*, Huang XF*. β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice. Microbiome. 2020, 8(1):143.
8.Yan C#, Fang F#, Zhang YZ, Dong X, Wu J, Liu HL, Fan CY, Koda S, Zhang BB, Yu Q, Wang L, Wang YG, Chen JX, Zheng KY*. Recombinant CsHscB of carcinogenic liver fluke Clonorchis sinensis induces IL-10 production by binding with TLR2. PLoS Negl Trop Dis 2020, 14(10): e0008643.
9.Yan C#,*, Wu J#, Xu N, Li J, Zhou QY, Yang HM, Cheng XD, Liu JX, Dong X, Koda S, Zhang BB, Yu Q, Chen JX, Tang RX, Zheng KY*. TLR4 Deficiency Exacerbates Biliary Injuries and Peribiliary Fibrosis Caused by Clonorchis sinensis in a Resistant Mouse Strain. Front Cell Infect Microbiol 2020, 10: 526997.
10.Yan C#, Wang L#, Li B, Zhang BB, Zhang B, Wang YH, Li XY, Chen JX, Tang RX*, Zheng KY*. The expression dynamics of transforming growth factor-beta/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis. Parasit Vectors 2015, 8: 70.
