Biography
Prof. Dr. WANG Wenshi serves as the Head of the Key Laboratory of Immunity and Metabolism of Jiangsu Province (Xuzhou Medical University). He is the Principal Investigator of the virus research group. He received his Ph.D. diploma from Erasmus University Rotterdam, the Netherlands, and successively carried out post-doc research work at Erasmus University Rotterdam in the Netherlands and Heidelberg University in Germany in the field of hepatitis viruses. He has published more than 60 SCI papers, with 20 first or corresponding authorship papers in top academic journals such as Journal of Hepatology, Gastroenterology, Hepatology, Trends in Microbiology, Science Signaling，PNAS and JHEP Reports. More information about Prof. Dr. Wang’s publication record can be accessed via the link below:
https://orcid.org/0000-0002-7330-262X
Academic Awards
Prof. Dr. WANG Wenshi received many prestigious academic awards in the field of Virology and Hepatology. For instance,
The Kiem Award from the Royal Netherlands Society for Microbiology
The 1st Prize NVGE Gastro-intestinal Research Award from the Netherlands Society of Gastroenterology
Selected as the cover character of the official journal "DDD NEWS" of the Netherlands Society of Gastroenterology
EASL Sheila Sherlock Fellowship from European Association for the Study of Liver
More information about Prof. Dr. Wang’s research group can be accessed via the link below:
https://www.x-mol.com/groups/wang_wenshi?lang=zh
Publications
Representative publications:
1.Guo H, Xu J, Situ J, Li C, Wang X, Hou Y, Yang G, Wang L, Ying D, Li Z, Wang Z, Su J, Ding Y, Zeng D, Zhang J, Ding X, Wu S, Miao W, Tang R, Lu Y, Kong H, Zhou P, Zheng Z, Zheng K, Pan X, Sridhar S, Wang W#. Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans. PNAS. 2024 Nov 5;121(45):e2416255121.
2.Guo H*#, Li Q*, Li C, Hou Y, Ding Y, Liu D, Ni Y, Tang R, Zheng K, Urban S, Wang W#. Molecular determinants within the C-termini of L-HDAg that regulate hepatitis D virus replication and assembly. JHEP Reports. 2024 Jan;6(1):100961.
3.Guo H*#, Liu D*, Liu K, Hou Y, Li C, Li Q, Ding X, Verstegen MMA, Zhang J, Wang L, Ding Y, Tang R, Pan X, Zheng K, van der Laan LJW, Pan Q, Wang W#. Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions. Virologica Sinica. 2024 Feb;39(1):123-133.
4.Ding Y, Guo H, Hong X, Li Q, Miao Z, Pan Q, Zheng K, Wang W. The distinct spatiotemporal evolutionary landscape of HBV and HDV largely determines the unique epidemic features of HDV globally. Mol Phylogenet Evol. 2024 Aug;197:108114.
5.Wenshi Wang#*; Florian A Lempp; Franziska Schlund; Lisa Walter; Charlotte Decker; Zhenfeng Zhang; Yi Ni; Stephan Urban; Assembly and infection efficacy of hepatitis B virus surface protein exchanges in eight hepatitis D virus genotype isolates, Journal of Hepatology, 2021.Apr, 75(2):311-323.
6.Sunrui Chen; Shihao Ding; Yuebang Yin; Lei Xu; Pengfei Li; Maikel P. Peppelenbosch; Qiuwei Pan; Wenshi Wang*; Suppression of pyrimidine biosynthesis by targeting DHODH enzyme robustly inhibits rotavirus replication, Antiviral Research, 2019, 167: 35-44.
7.Wenshi Wang; Yijin Wang; Changbo Qu; Shan Wang; Jianhua Zhou; Wanlu Cao; Lei Xu; Buyun Ma; Mohamad S. Hakim; Yuebang Yin; Tiancheng Li; Maikel P Peppelenbosch; Jingmin Zhao; Qiuwei Pan; The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response, Hepatology, 2018, 67(6): 2096-2112.
8.Wenshi Wang; Yuebang Yin; Lei Xu; Junhong Su; Fen Huang; Yijin Wang; Patrick P C Boor; Kan Chen; Wenhui Wang; Wanlu Cao; Xinying Zhou; Pengyu Liu; Luc J W van der Laan; Jaap Kwekkeboom; Maikel P Peppelenbosch; Qiuwei Pan; Unphosphorylated ISGF3 drives constitutive expression of interferon-stimulated genes to protect against viral infections, Science signaling, 2017, 10(476): 1-12.
9.Wenshi Wang; Lei Xu; Junhong Su; Maikel P Peppelenbosch; Qiuwei Pan ; Transcriptional Regulation of Antiviral Interferon-Stimulated Genes, Trends in Microbiology, 2017, 25(7): 573-584.
10.Wang W#, Hakim M. S.#, Nair V. P., de Ruiter P. E., Huang F., Sprengers D., Van Der Laan L. J., Peppelenbosch M. P., Surjit M., Pan Q. Distinct Antiviral Potency of Sofosbuvir Against Hepatitis C and E Viruses. Gastroenterology,2016, 151:1251-1253.
