Biography

Dr. Quangang Chen is an Associate Professor and Master’s Supervisor at Xuzhou Medical University. He has long been dedicated to teaching, research, and administrative work in laboratory animal science, animal infectious diseases, and the development of animal models for human diseases. He is particularly recognised for coining the concept of “porcineized mice” and has made major breakthroughs in this area, successfully generating porcineized mouse models susceptible to porcine reproductive and respiratory syndrome virus (PRRSV) as well as porcineized immune system mouse models. In recent years, he has also expanded his research into the discovery and engineering of shark-derived single-domain antibodies (VNARs). Leveraging their unique properties—small size, high stability, and deep tissue penetration—he focuses on developing VNAR-based diagnostic reagents and therapeutic candidates against infectious pathogens (e.g., PRRSV) and tumor-associated targets, aiming to bridge innovative biologics from bench to preclinical evaluation.

Dr. Chen has led a number of funded projects, including a General Program of the National Natural Science Foundation of China (No. 32172827), a Youth Program of the Jiangsu Provincial Natural Science Foundation (BK20170251), a Jiangsu Agricultural Science and Technology Innovation Project (CX(24)3076), and several municipal and university‑level grants.

Education

Huazhong Agricultural University 09/2008 – 06/2013 PhD

Liaocheng University, 09/2004 – 06/2008, Bachelor of Science in Agriculture      

Publications:

1. Chen Q, Chen Z, Xu D, Wang H, Hu A, Hu Z, Gao P, Li H, Li Y, Sun L, Gao K, Hou H, Di J, Chai K, Zhu B, Zhang Q, Wang G, Xu W, Han Z, Zheng J, Liu Y. Single- and dual-target CAR-T cells targeting HBsAg and GPC3 to balance safety and antitumor efficacy in HBV-positive hepatocellular carcinoma. iScience. 2026 Jul 21;29(8):116844.

2. A. Hu, Y. Guo, Y. Zhou, P. Chen, Y. Zhu, T. Liu, L. Wu, D. Qiao, Z. Huang, Y. Chen, X. Han, J. Liu, Q. Chen, Single-cell RNA sequencing analysis reveals a novel porcine alveolar macrophage subtype with high SLAMF7 expression promoting PRRSV infection, Virulence 16(1) (2025).

3. H. Wan, Y. Xu, T. Chen, Z. Wang, L. Sun, X. Wang, P. Wang, G. Liao, Z. Yuan, Q. Chen, Y. Pang, Engineering hierarchically porous carbon nitride nanofibers with controllable nitrogen defects for efficient solar-driven H2 generation, Chemical Engineering Journal 520 (2025).

4. Y. Chen, Y. Guo, A. Hu, Z. Xu, N. Bahadar, S. Xue, N. Chen, H. Zhang, J. Song, X. Li, J. Jiang, R. Chen, X. Lu, Q. Chen, Pan‐Cancer Analysis Identifies DIP2B as a Potential Biomarker That Inhibits Kidney Renal Clear Cell Carcinoma Progression, IUBMB Life 77(9) (2025).

5. L. Wu, Y. Zhu, Y. Qin, H. Yuan, L. Zhang, T. Lu, Q. Chen, A. Hu, Conditional Knockout of IL-1R1 in Endothelial Cells Attenuates Seizures and Neurodegeneration via Inhibiting Neuroinflammation Mediated by Nrf2/HO-1/NLRP3 Signaling in Status Epilepticus Model, Molecular Neurobiology 61(7) (2024) 4289–4303.

6. T. Liu, A. Hu, H. Chen, Y. Li, Y. Wang, Y. Guo, T. Liu, J. Zhou, D. Li, Q. Chen, Comprehensive analysis identifies DNA damage repair-related gene HCLS1 associated with good prognosis in lung adenocarcinoma, Translational Cancer Research 12(10) (2023) 2613–2628.

7. A. Hu, K. Tang, J. Liu, X. Han, Q. Chen, In silico analysis reveals PRR11 as a prognostic and oncogenic marker in lung adenocarcinoma, Medicine 102(21) (2023).

8. A. Hu, J. Liu, Y. Wang, M. Zhang, Y. Guo, Y. Qin, T. Liu, Y. Men, Q. Chen, T. Liu, Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer, Scientific Reports 13(1) (2023).

9. A. Hu, Y. Wang, J. Tian, Z. Chen, R. Chen, X. Han, Y. Chen, T. Liu, Q. Chen, Pan-cancer analysis reveals DDX21 as a potential biomarker for the prognosis of multiple tumor types, Frontiers in Oncology 12 (2022).

10. Y. Men, Y. Wang, H. Wang, M. Zhang, J. Liu, Y. Chen, X. Han, R. Chen, Q. Chen, A. Hu, RHDV 3C protein antagonizes type I interferon signaling by cleaving interferon promoter stimulated 1 protein, Virus Genes 59(2) (2022) 215–222.