Biography
Dr. Baole Zhang is a Professor in the Department of Cell Biology and Neurobiology at Xuzhou Medical University. He earned his PhD in Animal Genetics, Breeding, and Reproduction from Nanjing Agricultural University in 2012. Supported by a project funded by the China Postdoctoral Science Foundation, he completed his postdoctoral training at Xuzhou Medical University Affiliated Hospital and Nanjing Medical University in 2015. From March 2017 to March 2018, he was a visiting scholar at the Max Delbrück Center for Molecular Medicine in Germany, where he investigated the mechanisms by which microglia promote glioma development and progression. His current primary research focuses on the mechanisms underlying the pathogenesis and progression of gliomas and their drug resistance. He has led two projects funded by the National Natural Science Foundation of China, three provincial or ministerial-level projects, and three municipal or departmental-level projects. He has published over 29 SCI-indexed papers, which have been cited more than 511 times, and he has an H-index of 15. He also serves as a young editorial board member for Animal Advances and the Journal of Xuzhou Medical University, and as a reviewer for journals such as Carcinogenesis, Molecular Neurobiology, and the Chinese Journal of Biochemistry and Molecular Biology.
Education
Nanjing Agricultural University, 09/2007- 06/2012, Ph.D.
Qingdao Agricultural University, 09/2003- 07/2007, Bachelor of Science
Publications:
1. Yefeng Shi, Yang Zhang, Le Xu, Changwei Luo, Shun Xi, Xinyu Xu, Jianquan Liu, Haoyue Xu*, Baole Zhang**, Epigenetic upregulation of FGF2 promotes glioblastoma progression by enhancing the Warburg effect, Cellular Signalling, 2025, 135: 112011 (IF= 4.7)
2. Zimu Li, Shun Xi, Ziqi Zhang, Xugang Kan, Yang Zhang, Miaomiao Wang, Yudong Wang, Yefeng Shi, Haoyue Xu, Baole Zhang*, Hypoxic stress promotes astrocyte infiltration-like growth via HIF-1α/GDNF/LOXL2 axis, Biochimica et Biophysica Acta-Molecular Basis of Disease, 2025, 1871(3): 167702 (IF= 5.0)
3. Haibo Ni#, Xugang Kan#, Qin Rui , Yang Zhang, Weiwei Zhai, Baole Zhang*, Zhengquan Yu*, RACK1 promotes autophagy via the PERK signaling pathway to protect against traumatic brain injury in rats, CNS Neuroscience & Therapeutics, 2024, 30(3):e14691(IF= 5.0)
4. Haibo Ni #, Qin Rui #, Xugang Kan, Rong Gao, Li Zhang*, Baole Zhang*, Catalpol Ameliorates Oxidative Stress and Neuroinflammation after Traumatic Brain Injury in Rats, Neurochemical Research, 2023, 48(2):681-695 (IF= 3.7)
5. Miaomiao Wang# Xiao Han#, Wei Zha, Xiaoyu Wang, Liyun Liu, Zimu Li, Yefeng Shi, Xugang Kan, Gui Wang, Dianshuai Gao*, Baole Zhang*, GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis, Molecular Neurobiology, 2022, 59(10):6321-6340. (IF= 5.1)
6. Huang Yimin, Zhang Baole（Co-first authors）, Haneke Hannah, Haage Verena, Lubas Malgorzata, Yuan Yang, Xia Pengfei, Motta Edyta, Nanvuma Cynthia, Dzaye Omar, Hu Feng, Kettenmann Helmut*, GDNF increases MMP9 and MMP14 expression in microglia and promotes microglia mediated glioma progression. Journal of Neuroscience Research, 2021, 99(4):1048-1063. (IF= 4.4328)
7. Baole Zhang*, Xiao Han, Qing Gao, Jie Liu, Saisai Li, Wei Zha, Xiaoyu Wang, Xiaoxiao Guo, Dianshuai Gao*, Enhancer II-targeted dsRNA decreases GDNF expression via histone H3K9 trimethylation to inhibit glioblastoma progression. Brain Research Bulletin, 2021, 167: 22-32. (IF= 3.715)
8. Xin-Feng Liu, Chuan-Xi Tang, Lin Zhang, Shu-Yan Tong, Yue Wang, Ayanlaja Abiola Abdulrahman, Guang-Quan Ji, Yue Gao, Dian-Shuai Gao*, Bao-Le Zhang*, Down-regulated CUEDC2 increases GDNF expression by stabilizing CREB through reducing its ubiquitination in glioma. Neurochemical Research, 2020, 45(12):2915-2925. (IF=3.996)
9. Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo, Dianshuai Gao*, Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells. Clinical Epigenetics, 2020, 12(1):47 (IF=6.551)
10. Bao-Le Zhang, Fu-Lu Dong, Ting-Wen Guo, Xiao-He Gu, Lin-Yan Huang, Dian-Shuai Gao*, MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells. Cellular Physiology and Biochemistry, 2017, 44(5):1923-1938 (IF=5.5)
11. Bao-Le Zhang, Ting-Wen Guo, Le-Le Gao, Guang-Quan Ji, Xiao-He Gu，Yu-Qi Shao, Rui-Qin Yao，Dian-Shuai Gao*, Egr-1 and RNA POL II facilitate glioma cell GDNF transcription induced by histone hyperacetylation in promoter II. Oncotarget, 2017, 8(28):45105-45116 (IF=5.168)
12. Bao-Le Zhang, Jie Liu, Yu Lei, Ye Xiong, Heng Li, Xiaoqian Lin, Rui-Qin Yao, Dian-Shuai Gao*, An Epigenetic Mechanism of High Gdnf Transcription in Glioma Cells Revealed by Specific Sequence Methylation. Molecular Neurobiology, 2016, 53:4352-4362.(IF=6.19)
13. Bao-Le Zhang, Hai-Bo Ni, Jie Liu, Yu Lei, Heng Li, Ye Xiong, Zheng-Quan Yu, Dian-Shuai Gao*, Egr-1 participates in abnormally high gdnf gene transcription mediated by histone hyperacetylation in glioma cells. BBA-Gene Regulatory Mechanisms, 2014, 1839(11):1161-1169. (IF=6.332)
14. Zheng-Quan Yu, Bao-Le Zhang（Co-first authors）, Hai-bo Ni, Ze-Hao Liu, Jian-Cun Wang, Qing-Xian Ren, Jian-bing Mo, Ye Xiong, Rui-qin Yao, Dian-Shuai Gao*, Hyperacetylation of histone H3K9 involved in the promotion of abnormally high transcription of the gdnf gene in glioma cells. Molecular Neurobiology, 2014, 50: 914-922. (IF=5.137)
15. Zheng-Quan Yu*, Bao-Le Zhang（Co-first authors）, Qing-Xian Ren, Jian-Cun Wang, Ru-Tong Yu, De-Wei Qu, Ze-Hao Liu, Ye Xiong, Dian-Shuai Gao*, Changes in Transcriptional Factor Binding Capacity Resulting from Promoter Region Methylation Induce Aberrantly High GDNF Expression in Human Glioma. Molecular Neurobiology, 2013, 48:571–580. (IF=5.286)
16. Baole Zhang, Jianhua Ding, Ye Li, Jinjin Wang, Yongyan Zhao, Wei Wang, Shuai Shi, Fulu Dong, Fangxiong Shi and Yinxue Xu*, The Porcine Gpr3 Gene: Molecular Cloning, Characterization and Expression Level in Tissues and Cumulus–oocytes Complexes during in Vitro Maturation. Molecular Biology Report, 2012, 39(5): 5831-5839. (IF= 2.921)
17. Baole Zhang, Ye Li, Jianhua Ding, Fulu Dong, Yanjun Hou, Baochun Jiang, Fangxiong Shi and Yinxue Xu*, Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors. Journal of Zhe-jiang University Science B, 2012, 13(7): 555-566. (IF=1.108)
18. Baole ZHANG, Quanwei WEI, Shuai SHI, Fulu DONG, Fangxiong SHI and Yinxue XU*, Immunolocalization and expression pattern of Gpr3 in the ovary and its effect on proliferation of ovarian granulosa cells in pigs. Journal of Reproduction and Development, 2012, 58(4): 410-419. (IF= 1.755)
19. ZHANG Baole, LI Guo-qin, ZHANG He , SHEN Junda, LI Jinjun, TAO Zhengrong, CHEN Yichun, WANG Deqian, CHEN Wenbiao, SHI Fang-xiong* and LU Li-zhi*, Anas platyrhynchos BLVRA gene: molecular cloning and correlation between green shell character and mRNA expression in interstitial part of uterine tube in the duck，Chinese Journal of Animal and Veterinary Sciences, 1: 13-19, 2012.
20. Abiola Abdulrahman Ayanlaja, Baole Zhang, GuangQuan Ji, Yue Gao, Jie Wang, Kouminin Kanwore, and DianShuai Gao*, The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain. Seminars in cancer biology, 53: 212-222, 2018. (IF=10.198)
Awards & Honors
09/2019 Most favorite teacher of international students in 2018
11/2018 Second prize of Natural science Excellent Academic Paper in Xuzhou
09/2018 Second prize of Science and Technology Research Achievement Award (Natural Science Award) of University in Jiangsu
08/2016 First Prize of Natural science Excellent Academic Paper in Xuzhou
Patent
1. Baole Zhang, Dianshui Gao, Xiao Han, Jie Liu, Qing Gao, A dsRNA of enhancer II in GDNF gene promoter II region and its application. China Patent. Pending No. 202010259258.9. 2020.
2. Baole Zhang, Dianshui Gao, Jie Liu, Heng Li. A method for changes in the methylation level of specific cis-acting element in gene’s promoter at the living cell level. China Patent. Pending No. 201410723374.6. 2018.
3. Heng Li, Dianshui Gao, Baole Zhang, Xiang Chai, Tao He. A methods and primers of real-time PCR for detection of mouse GDNF splice variant-specific 2, 4. China Patent. Pending No. ZL 201310648187.1. 2015.
4. XU Yinxue, WANG Li, ZHANG Baole, Hou Yanjun. The medicament application of inhibitors in Wnt/β-catenin signal pathway to promote cell apoptosis. China Patent. Pending No. ZL201110197240.1. 2016.
