Biography
Dr. Jun Zhang is a Professor at the Department of Medical Biotechnology, Xuzhou Medical University. He received his Ph.D. in Developmental Biology from Beijing Normal University in 2015 and completed joint doctoral training in the Department of Cellular and Molecular Physiology at the Pennsylvania State University College of Medicine. He subsequently joined UT Health San Antonio as a postdoctoral fellow and was promoted to Assistant Professor in 2023.
His research focuses on the molecular mechanisms underlying mitochondrial dysfunction in aging and age-related diseases, with particular emphasis on mitochondrial phospholipids remodeling, cardiolipin metabolism, mitophagy, inflammation, and cellular senescence. He has published more than 20 SCI-indexed papers in leading journals, with more than 1100 citations and H-index of 20. He currently serves as a Review Editor for Frontiers journals and as an ad hoc reviewer for numerous international journals in aging, metabolism, and mitochondrial biology.
Education
Beijing Normal University, 09/2011 – 06/2015, PhD
Beijing Normal University, 09/2008 – 06/2011, Master of Science
Beijing Normal University, 09/2004 – 06/2008, Bachelor of Science
Publications:
1 Jun Zhang#, and Yuguang Shi. An upstream open reading frame (5’-uORF) links oxidative stress to translational control of ALCAT1 through phosphorylation of eIF2α. Free Radical Biology and Medicine, 2024, 214, 129-136.
2 Haoran Sun#, Jun Zhang#, Qianqian Ye, Xueling Liu, Xiaoyang Zhang, Fanyu Zeng, Jie Li, Yue Zheng, Xianlin Han, Chuan Su, and Yuguang Shi. LPGAT1 Controls MEGDEL Syndrome by Coupling Phosphatidylglycerol Remodeling with Mitochondrial Transport. Cell Reports, 2023, 42, 113214.
3 Jun Zhang#, Xueling Liu, Jia Nie, and Yuguang Shi. Restoration of Mitophagy Ameliorates Cardiomyopathy in Barth Syndrome. Autophagy, 2022, 18(9), 2134-2149.
4 Jun Zhang#, Jia Nie#, Haoran Sun#, Jie Li, John-Paul Andersen, and Yuguang Shi. De novo Labeling and Trafficking of Individual Lipid Species in Live Cells. Molecular Metabolism, 2022, 61, 101511.
5 Jun Zhang# and Yuguang Shi. In Search of the Holy Grail: Toward a Unified Hypothesis on Mitochondrial Dysfunction in Age-Related Diseases. Cells, 2022, 11(12), 1960.
6 Xueling Liu, Jun Zhang, Jie Li, Chengjie Song, and Yuguang Shi. Pharmacological Inhibition of ALCAT1 Mitigates Amyotrophic Lateral Sclerosis by Attenuating SOD1 Protein Aggregation. Molecular Metabolism, 2022, 101536.
7 Dandan Jia, Jun Zhang, Xueling Liu, John-Paul Andersen, Zhenjun Tian, Jia Nie, and Yuguang Shi. Insulin Resistance in Skeletal Muscle Selectively Protects the Heart in Response to Metabolic Stress. Diabetes, 2021, 70(10), 2333-2343.
8 Dandan Jia, Jun Zhang, Jia Nie, Xueling Liu, Zhenjun Tian, and Yuguang Shi. Cardiolipin Remodeling by ALCAT1 Links Hypoxia to Coronary Artery Disease by Promoting Mitochondrial Dysfunction. Molecular Therapy, 2021, 29(12), 3498-3511.
9 Jun Zhang#, John-Paul Andersen#, Haoran Sun, Xuyun Liu, Nahum Sonenberg, Jia Nie, and Yuguang Shi. Aster-C Coordinates with COP I Vesicles to Regulate Lysosomal Trafficking and Activation of mTORC1. EMBO Reports, 2020, 21(9), e49898.
10 John-Paul Andersen#, Jun Zhang#, Haoran Sun#, Xuyun Liu, Jiankang Liu, Jia Nie, and Yuguang Shi. Aster-B Coordinates with Arf1 to Regulate Mitochondrial Cholesterol Transport. Molecular Metabolism, 2020, 42, 101055.
