Biography
Joined Xuzhou Medical University in 2023, Department of Genetics, Lecturer. Teaches undergraduate courses including Medical Genetics, Genetics, and Systems Biology. Current research focuses on investigating the mechanisms underlying the development and progression of Type I neurofibromatosis, identifying therapeutic targets for neurofibromatosis, and developing drugs that enhance immune cell therapy. Has published 6 SCI papers as the first author in eLife, British Journal of Cancer and other journals, and applied for 2 invention patents. Funded research projects include the Young Scientists Fund of the National Natural Science Foundation of China and the Scientific Research Startup Fund for Excellent Talents of Xuzhou Medical University.
Publications (Last 5 Years)
1. Cheng Zhang; Sha sha Zhao; Huan Deng; Shihua Zhang; Juan Wang; Xiaoye Song; Deen Yu; Yue Zhang; Wen sheng Deng; STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis, eLife, 2023, 12(N/A)
2. Cheng Zhang; Juan Wang; Xiaoye Song; Deen Yu; Baoqiang Guo; Yaoyu Pang; Xiaomei Yin; Sha sha Zhao; Huan Deng; Shihua Zhang; Wen sheng Deng; STAT3 potentiates RNA polymerase I-directed transcription and tumor growth by activating RPA34 expression, British Journal of Cancer, 2022, 128(5)
3. Cheng Zhang; Houliang Zhao; Xiaoye Song; Juan Wang; Sha sha Zhao; Huan Deng; Liu He; Xiangyu Zhou; Xiaomei Yin; Kewei Zhang; Yue Zhang; Zhongyu Wu; Qiyue Chen; Jiannan Du; Deen Yu; Shihua Zhang; Wen sheng Deng; Transcription factor GATA4 drives RNA polymerase III-directedtranscription and transformed cell proliferation through a filamin A/GATA4/SP1 pathway, Journal of Biological Chemistry, 2022, 298(3): 101581
4. De'en Yu; Cheng Zhang; Yeman Zhou; Heng Yang; Chen Peng; Feng Zhang; Xinghua Liao; Yuan Zhu; Wen sheng Deng; Bo Li; Shihua Zhang; ncR2Met (lncR2meta sta v2.0): An updated database for experimentally supported ncRNAs during cancer metastatic events, Genomics, 2023, 115 (2)
5. Shihua Zhang; Cheng Zhang; Jinke Du; Rui Zhang; Shixiong Yang; Bo Li; Pingping Wang; Wen sheng Deng; Prediction of Lymph-Node Metastasis in Cancers Using Differentially Expressed mRNA and Non-coding RNA Signatures, Frontiers in Cell and Developmental Biology, 2021, 9 (N/A)
Research Projects (Last 5 Years)
1. Young Scientists Fund (Category C), Mechanism of KIF4A inducing malignant transformation of Type I neurofibromatosis by blocking the RASSF1A/Hippo signaling pathway, National Natural Science Foundation of China, 2025-01-01 to 2027-12-31, 300,000 RMB, In progress, Principal Investigator
2. General Program, Mining methods for cancer organotropic metastasis biomarkers based on single-cell differential network models, National Natural Science Foundation of China, 2022-01-01 to 2025-12-31, 600,000 RMB, Funding period ended, Participant
Research Patents (Last 5 Years)
1. Invention Patent Wensheng Deng ; Xiangyu Zhou ; Cheng Zhang ; A method for stably expressing secretable human insulin in mesenchymal stem cells, China, CN202110434985.9, 2022-07-01,
2. Invention Patent Wensheng Deng ; Cheng Zhang ; Shasha Zhao ; DNA gel extraction reagent and method for purifying PCR products using said reagent, CN201810632456.8, 2018-06-19, China,
