On September 10, the Jiangsu Key Laboratory of Immunity and Metabolism and the Jiangsu International Laboratory of Immunity and Metabolism werepublished a research paper entitled "A mouse protozoan boosts antigen-specific mucosal IgA responses in a specific lipid metabolism- and signaling-dependent manner " in Nature Communications (Top Journal of the 1st Region of the Chinese Academy of Sciences; The journal Nature Indices).Xuzhou Medical University is the first unit of the paper. Professor Yugang Wang is the corresponding author, and Associate Professor Yanbo Kou and graduate student Shenghan Zhang are co-first authors. The research work was supported by the National Natural Science Foundation of China, the Natural Science Foundation of Jiangsu Province, the Special Fund for Promoting Science and Technology Innovation of Xuzhou City, and the "Jiebangguashuai" project of Xuzhou Medical University.
Mucosal tissue is the body's first line of immune defense. Immunoglobulin A (IgA), as the most important antibody in mucosal tissue, is the key weapon of the mucosal barrier against pathogen infection. Although IgA has been known since the middle of the last century, the regulatory mechanisms of the IgA response are still not fully understood. This study systematically elucidates the interaction of gut microbiota or dietary source nutrients, host lipid metabolism, and host IgA response. The results showed that: 1. Intestinal symbiotic protozoa increased the content of arachidonic acid in the host intestine; 2. The accumulation of arachidonic acid in the intestine enhances the mucosal IgA response in an axial-dependent manner of arachidonic acid-leukotriene-leukotriene receptor; 3. The host mucosal IgA response enhanced by enteric symbiotic protozoa or dietary arachidonic acid can help the host resist enteric pathogen infection. This work provides a new idea for the prevention of mucosal infection and the study of mucosal vaccine adjuvants.
In recent years, the Jiangsu Key Laboratory of Immunity and Metabolism and the Jiangsu International Laboratory of Immunity and Metabolism have conducted basic and applied research on a series of major diseases based on the major national and local needs, starting from cross-disciplines and taking immunity and metabolism, intestinal microecology and host interaction as the basis. Research results have been published in PNAS, Hepatology, Journal of Clinical Investigation, Microbiome, Cancer Research, Cell Reports Medicine, Genome Medicine, Theranostics, Gut Microbes, and other international academic journals, declared or authorized more than 10 national invention patents.
Original link: https://www.nature.com/articles/s41467-024-52336-z
